RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition.

Bibliographic Details
Main Authors: Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, L. Francisco Lorenzo-Martín, Irene Barinaga-Rementería, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue, Xosé R. Bustelo, Adam Hurlstone, Piero Crespo
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05941-8

Internet

https://doi.org/10.1038/s41467-018-05941-8

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