SIRT1 regulates HIV transcription via Tat deacetylation.

SIRT1 regulates HIV transcription via Tat deacetylation.

The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase...

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Bibliographic Details
Main Authors: Sara Pagans, Angelika Pedal, Brian J North, Katrin Kaehlcke, Brett L Marshall, Alexander Dorr, Claudia Hetzer-Egger, Peter Henklein, Roy Frye, Michael W McBurney, Henning Hruby, Manfred Jung, Eric Verdin, Melanie Ott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC546329?pdf=render

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http://europepmc.org/articles/PMC546329?pdf=render

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