Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish

by Markus Westphal, Markus Westphal, Pooja Sant, Pooja Sant, Alexander-Thomas Hauser, Manfred Jung, Manfred Jung, Wolfgang Driever, Wolfgang Driever
Published 2020-02-01

Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

by Kristina King, Alexander-Thomas Hauser, Jelena Melesina, Wolfgang Sippl, Manfred Jung
Published 2018-02-01

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

by Adam Yasgar, Silviya D Furdas, David J Maloney, Ajit Jadhav, Manfred Jung, Anton Simeonov
Published 2012-01-01

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

by Lars Kaiser, Helga Weinschrott, Isabel Quint, Markus Blaess, René Csuk, Manfred Jung, Matthias Kohl, Hans-Peter Deigner
Published 2020-08-01

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

by Jens Köhler, German Erlenkamp, Adrien Eberlin, Tobias Rumpf, Inna Slynko, Eric Metzger, Roland Schüle, Wolfgang Sippl, Manfred Jung
Published 2012-01-01

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

by Berin Karaman, Zayan Alhalabi, Sören Swyter, Shetonde O. Mihigo, Kerstin Andrae-Marobela, Manfred Jung, Wolfgang Sippl, Fidele Ntie-Kang
Published 2018-02-01

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

by Julien Lancelot, Stéphanie Caby, Florence Dubois-Abdesselem, Mathieu Vanderstraete, Jacques Trolet, Guilherme Oliveira, Franz Bracher, Manfred Jung, Raymond J Pierce
Published 2013-01-01

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

by Christoph W. Grathwol, Nathalie Wössner, Sören Swyter, Adam C. Smith, Enrico Tapavicza, Robert K. Hofstetter, Anja Bodtke, Manfred Jung, Andreas Link
Published 2019-09-01

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

by Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin
Published 2019-10-01

Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

by Daqiang Pan, Michel Kather, Lucas Willmann, Manuel Schlimpert, Christoph Bauer, Simon Lagies, Karin Schmidtkunz, Steffen U. Eisenhardt, Manfred Jung, Stefan Günther, Bernd Kammerer
Published 2016-10-01

Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases

by Nathalie Wössner, Zayan Alhalabi, Jessica González, Sören Swyter, Jin Gan, Karin Schmidtkunz, Lin Zhang, Alejandro Vaquero, Huib Ovaa, Oliver Einsle, Wolfgang Sippl, Manfred Jung
Published 2020-04-01

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes

by Martin Hügle, Xavier Lucas, Gerhard Weitzel, Dmytro Ostrovskyi, Bernhard Breit, Stefan Gerhardt, Karin Schmidtkunz, Manfred Jung, Roland Schüle, Oliver Einsle, Stefan Günther, Daniel Wohlwend
Published 2016-06-01

Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development

by Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen, Maja T. Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B. Huber, Nicola Wanner
Published 2021-04-01

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

by Conrad V. Simoben, Dina Robaa, Alokta Chakrabarti, Karin Schmidtkunz, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, Tajith B. Shaik, Raymond J. Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl
Published 2018-03-01

Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis.

by Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Eduardo José Lopes Torres, Stephany Caby, Julien Lancelot, Mathieu Vanderstraete, Silviya D Furdas, Manfred Jung, Raymond J Pierce, Marcelo Rosado Fantappié
Published 2014-05-01

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.

by Hugo Rolando Vaca, Ana María Celentano, María Agustina Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira, María Celina Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit
Published 2021-03-01

SIRT1 regulates HIV transcription via Tat deacetylation.

by Sara Pagans, Angelika Pedal, Brian J North, Katrin Kaehlcke, Brett L Marshall, Alexander Dorr, Claudia Hetzer-Egger, Peter Henklein, Roy Frye, Michael W McBurney, Henning Hruby, Manfred Jung, Eric Verdin, Melanie Ott
Published 2005-02-01

Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors

by Chiara Luise, Dina Robaa, Pierre Regenass, David Maurer, Dmytro Ostrovskyi, Ludwig Seifert, Johannes Bacher, Teresa Burgahn, Tobias Wagner, Johannes Seitz, Holger Greschik, Kwang-Su Park, Yan Xiong, Jian Jin, Roland Schüle, Bernhard Breit, Manfred Jung, Wolfgang Sippl
Published 2021-05-01

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

by Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J Pierce, Christophe Romier
Published 2013-01-01