RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes

RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes

The potent proinflammatory cytokine interleukin (IL)-1 triggers gene expression through the NF-κB signaling pathway. Here, we investigated the cofactor requirements of strongly regulated IL-1 target genes whose expression is impaired in p65 NF-κB-deficient murine embryonic fibroblasts. By two indepe...

Full description

Bibliographic Details
Main Authors: Johanna Meier-Soelch, Liane Jurida, Axel Weber, Doris Newel, Johnny Kim, Thomas Braun, M. Lienhard Schmitz, Michael Kracht
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
IL-1
corepressor
coactivator
NF-κB
transcription
chromatin
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00775/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00775/full

Similar Items