Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study

Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study

Currently, there is an increasing interest to apply pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) as antigen for the development of a subunit vaccine. A pre-F-containing powder would increase the flexibility regarding the route of administration. For instance, a pre-F-containing po...

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Bibliographic Details
Main Authors: Max Beugeling, Katie Amssoms, Freek Cox, Ben De Clerck, Ellen Van Gulck, Jeroen A. Verwoerd, Guenter Kraus, Dirk Roymans, Lieven Baert, Henderik W. Frijlink, Wouter L. J. Hinrichs
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceutics
Subjects:
biphasic pulsatile release
controlled release
freeze-dried powder
fusion protein
poly(<span style="font-variant: small-caps">dl</span>-lactic-<i>co</i>-glycolic acid)
pre-fusion
respiratory syncytial virus
single-injection vaccine
Online Access:https://www.mdpi.com/1999-4923/11/10/510

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https://www.mdpi.com/1999-4923/11/10/510

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