Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is observed in several conditions including in sporadic PD brain,...

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Bibliographic Details
Main Authors: Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Phosphatases
Phosphorylation
Ubiquitination
Parkinson's disease
PP2A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001753

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http://www.sciencedirect.com/science/article/pii/S0969996121001753

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