Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is compelling evidence to suggest that progressio...

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Bibliographic Details
Main Authors: Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Neurobiology of Disease
Subjects:
Misfolded
SNCA
Antibody
Immunotherapy
Animal model
Transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303870

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119303870

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