Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes

Parasites tend to evolve small and compact genomes, generally endowed with a high mutation rate, compared with those of their free-living relatives. However, the mechanisms by which they achieve these features, independently in unrelated lineages, remain largely unknown. We argue that the loss of th...

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Bibliographic Details
Main Authors: Anna Nenarokova, Kristína Záhonová, Marija Krasilnikova, Ondřej Gahura, Richard McCulloch, Alena Zíková, Vyacheslav Yurchenko, Julius Lukeš
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.01541-19