Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children

Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children

Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mech...

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Bibliographic Details
Main Authors: Gregory K Friedman, Elizabeth A Beierle, George Yancey Gillespie, James M Markert, Alicia M Waters, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, Timothy P Cripe
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300183

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http://www.sciencedirect.com/science/article/pii/S2372770516300183

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