iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.

Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of Leishmania growth absolutely requires expression of inducible Nitric Oxide Synthase (iNOS/NOS2) and subsequent production of NO. Here, we show that CD11b+ CD11c+ Ly-6C+ MHC-II+ c...

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Bibliographic Details
Main Authors: Carl De Trez, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Eric Muraille
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2695779?pdf=render

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http://europepmc.org/articles/PMC2695779?pdf=render

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