Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.

by Hideki Sanjo, Shigeo Tokumaru, Shizuo Akira, Shinsuke Taki
Published 2015-01-01

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

by Rabindra N Bhattacharjee, Birendranath Banerjee, Shizuo Akira, M Prakash Hande
Published 2010-07-01

Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection.

by François Coulombe, Stéphanie Fiola, Shizuo Akira, Yvon Cormier, Jean Gosselin
Published 2012-01-01

Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice.

by Toru Hosoi, Shota Yokoyama, Suguru Matsuo, Shizuo Akira, Koichiro Ozawa
Published 2010-01-01

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.

by Carl De Trez, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Eric Muraille
Published 2009-06-01

Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages.

by Masa Tsuchiya, Vincent Piras, Sangdun Choi, Shizuo Akira, Masaru Tomita, Alessandro Giuliani, Kumar Selvarajoo
Published 2009-01-01

Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif.

by Issa Abu-Dayyeh, Marina Tiemi Shio, Shintaro Sato, Shizuo Akira, Benoit Cousineau, Martin Olivier
Published 2008-01-01

Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.

by Linda M Bradley, Mia F Douglass, Dhrubamitra Chatterjee, Shizuo Akira, Bas J G Baaten
Published 2012-01-01

Distinct modulated pupil function system for real-time imaging of living cells.

by Tomonobu M Watanabe, Yoshikazu Tsukasaki, Hideaki Fujita, Taro Ichimura, Tatsuya Saitoh, Shizuo Akira, Toshio Yanagida
Published 2012-01-01

ILC2s Improve Glucose Metabolism Through the Control of Saturated Fatty Acid Absorption Within Visceral Fat

by Takuro Okamura, Yoshitaka Hashimoto, Jun Mori, Mihoko Yamaguchi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Hiroshi Takakuwa, Takashi Satoh, Takashi Satoh, Shizuo Akira, Shizuo Akira, Masahide Hamaguchi, Michiaki Fukui
Published 2021-07-01

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

by Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira
Published 2016-03-01

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.

by Martin Kreutz, Benoit Giquel, Qin Hu, Ram Abuknesha, Satoshi Uematsu, Shizuo Akira, Frank O Nestle, Sandra S Diebold
Published 2012-01-01

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

by Masahisa Hemmi, Masashi Tachibana, Masashi Tachibana, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Fuminori Sakurai, Kouji Kobiyama, Kouji Kobiyama, Ken J. Ishii, Ken J. Ishii, Shizuo Akira, Shizuo Akira, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi
Published 2017-11-01

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

by Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
Published 2017-09-01

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.

by Daisuke Fujikura, Satoko Chiba, Daisuke Muramatsu, Mika Kazumata, Yosuke Nakayama, Taro Kawai, Shizuo Akira, Hiroshi Kida, Tadaaki Miyazaki
Published 2013-01-01

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway.

by Masahiro Fukasaka, Daisuke Asari, Eiji Kiyotoh, Arimichi Okazaki, Yasuyuki Gomi, Takeshi Tanimoto, Osamu Takeuchi, Shizuo Akira, Mitsuhiko Hori
Published 2015-01-01

Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

by Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya
Published 2010-01-01

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

by Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto
Published 2015-10-01

Signaling flux redistribution at toll-like receptor pathway junctions.

by Kumar Selvarajoo, Yasunari Takada, Jin Gohda, Mohamed Helmy, Shizuo Akira, Masaru Tomita, Masa Tsuchiya, Jun-Ichiro Inoue, Koichi Matsuo
Published 2008-01-01

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease

by Yuri Ikeda-Matsuo, Hajime Miyata, Tomoko Mizoguchi, Eisaku Ohama, Yasuhito Naito, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki, Mitsuo Tanabe
Published 2019-04-01