Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice

by Jean Pierre Kambala Mukendi, Risa Nakamura, Satoshi Uematsu, Shinjiro Hamano
Published 2021-01-01

Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System

by Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Daiki Yamamoto, Sean Nelson, Satoshi Uematsu, Satoshi Uematsu, Satoshi Uematsu, Peter B. Ernst, Peter B. Ernst, Peter B. Ernst, Toshinori Nakayama, Toshinori Nakayama, Toshinori Nakayama, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono
Published 2017-12-01

MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.

by Timothy Sheahan, Thomas E Morrison, William Funkhouser, Satoshi Uematsu, Shizou Akira, Ralph S Baric, Mark T Heise
Published 2008-12-01

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.

by Martin Kreutz, Benoit Giquel, Qin Hu, Ram Abuknesha, Satoshi Uematsu, Shizuo Akira, Frank O Nestle, Sandra S Diebold
Published 2012-01-01

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease

by Yuri Ikeda-Matsuo, Hajime Miyata, Tomoko Mizoguchi, Eisaku Ohama, Yasuhito Naito, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki, Mitsuo Tanabe
Published 2019-04-01

Dysbiotic Fecal Microbiome in HIV-1 Infected Individuals in Ghana

by Prince Kofi Parbie, Prince Kofi Parbie, Prince Kofi Parbie, Taketoshi Mizutani, Aya Ishizaka, Ai Kawana-Tachikawa, Ai Kawana-Tachikawa, Ai Kawana-Tachikawa, Lucky Ronald Runtuwene, Sayuri Seki, Christopher Zaab-Yen Abana, Dennis Kushitor, Evelyn Yayra Bonney, Sampson Badu Ofori, Satoshi Uematsu, Satoshi Uematsu, Satoshi Uematsu, Seiya Imoto, Seiya Imoto, Yasumasa Kimura, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Koichi Ishikawa, William Kwabena Ampofo, Tetsuro Matano, Tetsuro Matano, Tetsuro Matano
Published 2021-05-01

Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice.

by Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon
Published 2011-02-01

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

by Adriana Flores-Langarica, Charlotte Cook, Katarzyna Müller Luda, Emma K. Persson, Jennifer L. Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J. Persson, Satoshi Uematsu, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Bengt Johansson Lindbom, Bengt Johansson Lindbom, William Agace, William Agace, Adam F. Cunningham
Published 2018-10-01

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adju...

by Steven E. Applequist, Shizuo Akira, Jorma Hinkula, Daniel X. Johansson, Ulf Schröder, Satoshi Uematsu, Björn Rissiek, Claudia Devito, Andreas Bråve, Tina Falkeborn, Sanna Nyström
Published 2013-09-01

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

by Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
Published 2009-07-01

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

by Ryo Takahashi, Hideki Amano, Yoshiya Ito, Koji Eshima, Takefumi Satoh, Masatsugu Iwamura, Masaki Nakamura, Hidero Kitasato, Satoshi Uematsu, Joan Raouf, Per-Johan Jakobsson, Shizuo Akira, Masataka Majima
Published 2020-01-01

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

by Takeshi Yamamoto, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Hikari K. Asou, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Satoshi Uematsu, Hiroshi Nishimasu, Osamu Nureki, Damon J. Tumes, Naoki Shimojo, Toshinori Nakayama
Published 2018-10-01

Diet-Induced Obese Mice and Leptin-Deficient <i>Lep^ob/ob</i> Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

by Eunyoung Lee, Emily L. Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig, Fiona M. Gribble, Frank Reimann, Takashi Miki
Published 2019-09-01

Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.

by Stefan Schülke, Sonja Wolfheimer, Gabriele Gadermaier, Andrea Wangorsch, Susanne Siebeneicher, Peter Briza, Ingo Spreitzer, Dirk Schiller, Bettina Loeschner, Satoshi Uematsu, Bernard Ryffel, Shizuo Akira, Zoe Waibler, Stefan Vieths, Masako Toda, Stephan Scheurer
Published 2014-01-01

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids

by Yu Takahashi, Shintaro Sato, Yosuke Kurashima, Tomohisa Yamamoto, Shiho Kurokawa, Yoshikazu Yuki, Naoki Takemura, Satoshi Uematsu, Chen-Yi Lai, Makoto Otsu, Hiroshi Matsuno, Hideki Osawa, Tsunekazu Mizushima, Junichi Nishimura, Mikio Hayashi, Takayuki Yamaguchi, Hiroshi Kiyono
Published 2018-01-01

Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial

by Yoshikazu Yuki, PhD, Masanori Nojima, MD, Osamu Hosono, MD, Hirotoshi Tanaka, ProfMD, Yasumasa Kimura, PhD, Takeshi Satoh, PhD, Seiya Imoto, ProfPhD, Satoshi Uematsu, ProfMD, Shiho Kurokawa, PhD, Koji Kashima, PhD, Mio Mejima, PhD, Rika Nakahashi-Ouchida, PhD, Yohei Uchida, MS, Takanori Marui, MS, Noritada Yoshikawa, MD, Fumitaka Nagamura, ProfMD, Kohtaro Fujihashi, ProfDDS, Hiroshi Kiyono, ProfDDS
Published 2021-09-01