Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.

The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. Difficulties related to...

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Bibliographic Details
Main Authors: Hasier Eraña, Jorge M Charco, Michele A Di Bari, Carlos M Díaz-Domínguez, Rafael López-Moreno, Enric Vidal, Ezequiel González-Miranda, Miguel A Pérez-Castro, Sandra García-Martínez, Susana Bravo, Natalia Fernández-Borges, Mariví Geijo, Claudia D'Agostino, Joseba Garrido, Jifeng Bian, Anna König, Boran Uluca-Yazgi, Raimon Sabate, Vadim Khaychuk, Ilaria Vanni, Glenn C Telling, Henrike Heise, Romolo Nonno, Jesús R Requena, Joaquín Castilla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008117

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https://doi.org/10.1371/journal.ppat.1008117

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