Footprints of antigen processing boost MHC class II natural ligand predictions

Footprints of antigen processing boost MHC class II natural ligand predictions

Abstract Background Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, generated in vitro and therefore lacking information about antigen proc...

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Bibliographic Details
Main Authors: Carolina Barra, Bruno Alvarez, Sinu Paul, Alessandro Sette, Bjoern Peters, Massimo Andreatta, Søren Buus, Morten Nielsen
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Medicine
Subjects:
MHC-II
Binding predictions
Eluted ligands
T cell epitope
Neural networks
Antigen processing
Online Access:http://link.springer.com/article/10.1186/s13073-018-0594-6

Internet

http://link.springer.com/article/10.1186/s13073-018-0594-6

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