Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia

Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a common, yet underdiagnosed, genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol levels, which can increase the risk of early-onset coronary artery disease (CAD). In the present study, we screened the nucleotide variations of...

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Bibliographic Details
Main Authors: Arman Moradi, Majid Maleki, Zahra Ghaemmaghami, Zahra Khajali, Feridoun Noohi, Maryam Hosseini Moghadam, Samira Kalyinia, Seyed Javad Mowla, Nabil G. Seidah, Mahshid Malakootian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Genetics
Subjects:
pre-mature CAD
Familial Hypercholesterolemia
loss-of-function
LDLR
PCSK9 (proprotein convertase subtilisin kexin type 9)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.625959/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.625959/full

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