HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating durable and specific immunity against these H...

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Bibliographic Details
Main Authors: Christian Grunwitz, Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Thomas Bukur, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Ugur Sahin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-09-01
Series:OncoImmunology
Subjects:
cancer vaccine
hpv16-positive malignancies
hpv 16 rna-lpx
e7
t cell memory
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1629259

Internet

http://dx.doi.org/10.1080/2162402X.2019.1629259

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