Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis.

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis.

Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella. Here we investigated the role of MyD88 in myeloid and endothelial cells during Klebsiella pneumosepsis. M...

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Bibliographic Details
Main Authors: Miriam H P van Lieshout, Adam A Anas, Sandrine Florquin, Baidong Hou, Cornelis van't Veer, Alex F de Vos, Tom van der Poll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4177915?pdf=render

Internet

http://europepmc.org/articles/PMC4177915?pdf=render

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