Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Abstract Background We have evaluated the efficacy of targeting the toxic, oligomeric form of tau protein by passive immunotherapy in a mouse model of synucleinopathy. Parkinson’s disease and Lewy body dementia are two of the most common neurodegenerative disorders and are primarily characterized by...

Full description

Bibliographic Details
Main Authors: Julia E. Gerson, Kathleen M. Farmer, Natalie Henson, Diana L. Castillo-Carranza, Mariana Carretero Murillo, Urmi Sengupta, Alan Barrett, Rakez Kayed
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Immunotherapy
Oligomers
α-synuclein
Synucleinopathies
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0245-9

Internet

http://link.springer.com/article/10.1186/s13024-018-0245-9

Similar Items