Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis

Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis

While 1 to 2% of amyotrophic lateral sclerosis (ALS) is caused by mutations in the SOD1 gene, the basis of the remaining instances of inherited disease is unknown. Neuropathology, mouse modeling, and human genetics have implicated neurofilaments in the pathogenesis of motor neuron diseases such as A...

Full description

Bibliographic Details
Main Authors: Michael L. Garcia, Andrew B. Singleton, Dena Hernandez, Christopher M. Ward, Crystal Evey, Peter A. Sapp, John Hardy, Robert H. Brown, Jr., Don W. Cleveland
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Neurobiology of Disease
Subjects:
ALS
Motor neuron disease
Neurofilaments
SOD1
Mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001920

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105001920

Similar Items