Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

Abstract Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Results Here, we explored the effect of defined genetic changes on the transcriptome, proteome and phosphoproteome in twelve tumors...

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Bibliographic Details
Main Authors: Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Marco Colombi, Dritan Liko, Charlotte K. Y. Ng, Salvatore Piscuoglio, Jonas Behr, Ariane L. Moore, Jochen Singer, Hans-Joachim Ruscheweyh, Matthias S. Matter, Dirk Mossmann, Luigi M. Terracciano, Michael N. Hall, Niko Beerenwinkel
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Genomics
Subjects:
HCC
mTOR signaling
NetICS
Omics
Online Access:https://doi.org/10.1186/s12864-021-07876-9

Internet

https://doi.org/10.1186/s12864-021-07876-9

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