Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...

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Bibliographic Details
Main Authors: Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
Format: Article
Language:English
Published: The Company of Biologists 2021-02-01
Series:Disease Models & Mechanisms
Subjects:
trachea
tracheomalacia
cartilage
hedgehog
Online Access:http://dmm.biologists.org/content/14/2/dmm046573

Internet

http://dmm.biologists.org/content/14/2/dmm046573

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