Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.

BACKGROUND:The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are unclear. Understanding how global perturbations in metabolism are related to severity of AD neuropathology and the eventual expres...

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Main Authors: Vijay R Varma, Anup M Oommen, Sudhir Varma, Ramon Casanova, Yang An, Ryan M Andrews, Richard O'Brien, Olga Pletnikova, Juan C Troncoso, Jon Toledo, Rebecca Baillie, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, P Murali Doraiswamy, Andrew J Saykin, Rima Kaddurah-Daouk, Cristina Legido-Quigley, Madhav Thambisetty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC5784884?pdf=render

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http://europepmc.org/articles/PMC5784884?pdf=render

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