Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 that the first infection(s) with influenza virus leaves a special immunological imprint which shapes immune responses to future infections with antigenically related influenza virus strains. Imprinting...

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Bibliographic Details
Main Authors: Philip Meade, Guillermina Kuan, Shirin Strohmeier, Hannah E. Maier, Fatima Amanat, Angel Balmaseda, Kimihito Ito, Ericka Kirkpatrick, Andres Javier, Lionel Gresh, Raffael Nachbagauer, Aubree Gordon, Florian Krammer
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
influenza virus
natural infection
imprinting
heterosubtypic immunity
cross-reactivity
influenza
Online Access:https://doi.org/10.1128/mBio.03243-19

Internet

https://doi.org/10.1128/mBio.03243-19

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