Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.

The transcription factor Nrf2 (NF-E2-related factor 2) and its target gene products, including heme oxygenase-1 (HO-1), elicit an antioxidant response that may have therapeutic value for Parkinson's disease (PD). However, HO-1 protein levels are increased in dopaminergic neurons of Parkinson�...

Full description

Bibliographic Details
Main Authors: Nadia G Innamorato, Agnieszka Jazwa, Ana I Rojo, Concepción García, Javier Fernández-Ruiz, Anna Grochot-Przeczek, Anna Stachurska, Alicja Jozkowicz, Jozef Dulak, Antonio Cuadrado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2911386?pdf=render

Internet

http://europepmc.org/articles/PMC2911386?pdf=render

Similar Items