In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis. Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development. However, balan...

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Bibliographic Details
Main Authors: Antony M Latham, Jayakanth Kankanala, Gareth W Fearnley, Matthew C Gage, Mark T Kearney, Shervanthi Homer-Vanniasinkam, Stephen B Wheatcroft, Colin W G Fishwick, Sreenivasan Ponnambalam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4230991?pdf=render

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http://europepmc.org/articles/PMC4230991?pdf=render

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