Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

Alzheimer’s disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-β (Aβ), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosis of the secosteroid vitamin D and AD. Beside...

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Bibliographic Details
Main Authors: Marcus O. W. Grimm, Andrea Thiel, Anna A. Lauer, Jakob Winkler, Johannes Lehmann, Liesa Regner, Christopher Nelke, Daniel Janitschke, Céline Benoist, Olga Streidenberger, Hannah Stötzel, Kristina Endres, Christian Herr, Christoph Beisswenger, Heike S. Grimm, Robert Bals, Frank Lammert, Tobias Hartmann
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D
vitamin D analogues
amyloid precursor protein
amyloid-β
secretases
Aβ-degradation
Online Access:https://www.mdpi.com/1422-0067/18/12/2764

Internet

https://www.mdpi.com/1422-0067/18/12/2764

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