Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in...

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Bibliographic Details
Main Authors: Damien C Tully, Colin B Ogilvie, Rebecca E Batorsky, David J Bean, Karen A Power, Musie Ghebremichael, Hunter E Bedard, Adrianne D Gladden, Aaron M Seese, Molly A Amero, Kimberly Lane, Graham McGrath, Suzane B Bazner, Jake Tinsley, Niall J Lennon, Matthew R Henn, Zabrina L Brumme, Philip J Norris, Eric S Rosenberg, Kenneth H Mayer, Heiko Jessen, Sergei L Kosakovsky Pond, Bruce D Walker, Marcus Altfeld, Jonathan M Carlson, Todd M Allen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005619

Internet

https://doi.org/10.1371/journal.ppat.1005619

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