The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), which is uniquely permissive for V-DJβ recombination;...

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Bibliographic Details
Main Authors: Karen S Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J Hodes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108609?pdf=render

Internet

http://europepmc.org/articles/PMC3108609?pdf=render

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