Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Abstract Background Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy...

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Bibliographic Details
Main Authors: Niklas Mattsson, Rik Ossenkoppele, Ruben Smith, Olof Strandberg, Tomas Ohlsson, Jonas Jögi, Sebastian Palmqvist, Erik Stomrud, Oskar Hansson
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
APOE
Tau
Atrophy
Cognition
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-018-0403-x

Internet

http://link.springer.com/article/10.1186/s13195-018-0403-x

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