Disruptive Selection of Human Immunostimulatory and Immunosuppressive Genes Both Provokes and Prevents Rheumatoid Arthritis, Respectively, as a Self-Domestication Syndrome

Disruptive Selection of Human Immunostimulatory and Immunosuppressive Genes Both Provokes and Prevents Rheumatoid Arthritis, Respectively, as a Self-Domestication Syndrome

Using our previously published Web service SNP_TATA_Comparator, we conducted a genome-wide study of single-nucleotide polymorphisms (SNPs) within core promoters of 68 human rheumatoid arthritis (RA)-related genes. Using 603 SNPs within 25 genes clinically associated with RA-comorbid disorders, we pr...

Full description

Bibliographic Details
Main Authors: Natalya V. Klimova, Evgeniya Oshchepkova, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Irina Drachkova, Dmitry Rasskazov, Dmitry Oshchepkov, Mikhail Ponomarenko, Ludmila Savinkova, Nikolay A. Kolchanov, Vladimir Kozlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
rheumatoid arthritis
human
gene
promoter
TATA box
candidate SNP marker
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.610774/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.610774/full

Similar Items