Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.

Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.

The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various mechanisms r...

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Bibliographic Details
Main Authors: Umesh B Masharani, Betty A Maddux, Xiaojuan Li, Giorgos K Sakkas, Kathleen Mulligan, Morris Schambelan, Ira D Goldfine, Jack F Youngren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3092773?pdf=render

Internet

http://europepmc.org/articles/PMC3092773?pdf=render

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