Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various mechanisms r...
Main Authors: | Umesh B Masharani, Betty A Maddux, Xiaojuan Li, Giorgos K Sakkas, Kathleen Mulligan, Morris Schambelan, Ira D Goldfine, Jack F Youngren |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-05-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3092773?pdf=render |
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