Bioactivity Studies of β-Lactam Derived Polycyclic Fused Pyrroli-Dine/Pyrrolizidine Derivatives in Dentistry: In Vitro, In Vivo and In Silico Studies.

Bioactivity Studies of β-Lactam Derived Polycyclic Fused Pyrroli-Dine/Pyrrolizidine Derivatives in Dentistry: In Vitro, In Vivo and In Silico Studies.

The antibacterial activity of β-lactam derived polycyclic fused pyrrolidine/pyrrolizidine derivatives synthesized by 1, 3-dipolar cycloaddition reaction was evaluated against microbes involved in dental infection. Fifteen compounds were screened; among them compound 3 showed efficient antibacterial...

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Main Authors: Gowri Meiyazhagan, Rajesh Raju, Sofi Beaula Winfred, Bhavani Mannivanan, Hemadev Bhoopalan, Venkatesh Shankar, Sathiya Sekar, Deepa Parvathi Venkatachalam, Ravishankar Pitani, Venkateshbabu Nagendrababu, Malini Thaiman, Kandaswamy Devivanayagam, Jeyakanthan Jayaraman, Raghunathan Ragavachary, Ganesh Venkatraman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0131433

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https://doi.org/10.1371/journal.pone.0131433

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