SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

SS1P is an anti-mesothelin immunotoxin composed of a targeting antibody fragment genetically fused to a truncated fragment of Pseudomonas exotoxin A. Delayed responses reported in mesothelioma patients receiving SS1P suggest that anti-tumor immunity is induced. The goal of this study is to evaluate...

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Bibliographic Details
Main Authors: Yasmin Leshem, Emily M. King, Ronit Mazor, Yoram Reiter, Ira Pastan
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Toxins
Subjects:
immunotoxins
SS1P
anti-CTLA-4
mesothelioma
mesothelin
immunogenic cell death
immunotherapy
ATP
Calreticulin
Online Access:https://www.mdpi.com/2072-6651/10/11/470

Internet

https://www.mdpi.com/2072-6651/10/11/470

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