New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

We report the synthesis of several related 4-anilinoquinazolines as inhibitors of cardiac troponin I–interacting kinase (TNNi3K). These close structural analogs of 3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-<i>N</i>-methylbenzenesulfonamide (GSK114) provide new understandi...

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Bibliographic Details
Main Authors: Christopher R. M. Asquith, Tuomo Laitinen, Carrow I. Wells, Graham J. Tizzard, William J. Zuercher
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
cardiac troponin I–interacting kinase (TNNi3K)
4-anilino-quinazolines
conformational flexibility
hinge binder
kinase inhibitor design
Online Access:https://www.mdpi.com/1420-3049/25/7/1697

Internet

https://www.mdpi.com/1420-3049/25/7/1697

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