Dynamic Cellular Integration Drives Functional Assembly of the Heart’s Pacemaker Complex

Summary: Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment....

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Bibliographic Details
Main Authors: Michael Bressan, Trevor Henley, Jonathan D. Louie, Gary Liu, Danos Christodoulou, Xue Bai, Joan Taylor, Christine E. Seidman, J.G. Seidman, Takashi Mikawa
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830634X