Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisation and gain mechanistic insight into their modes of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-12-01
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| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-020-00412-y |