Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients’ brains, the underlying mechanisms of neurodegeneration in FTD are poorly und...

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Bibliographic Details
Main Authors: Marc Ehrlich, Anna-Lena Hallmann, Peter Reinhardt, Marcos J. Araúzo-Bravo, Sabrina Korr, Albrecht Röpke, Olympia E. Psathaki, Petra Ehling, Sven G. Meuth, Adrian L. Oblak, Jill R. Murrell, Bernardino Ghetti, Holm Zaehres, Hans R. Schöler, Jared Sterneckert, Tanja Kuhlmann, Gunnar Hargus
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115001824

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http://www.sciencedirect.com/science/article/pii/S2213671115001824

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