Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides...

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Bibliographic Details
Main Authors: Claudia Tulotta, Cristina Stefanescu, Elena Beletkaia, Jeroen Bussmann, Katsiaryna Tarbashevich, Thomas Schmidt, B. Ewa Snaar-Jagalska
Format: Article
Language:English
Published: The Company of Biologists 2016-02-01
Series:Disease Models & Mechanisms
Subjects:
CXCR4
CXCL12
IT1t
Triple-negative breast cancer
Metastases
Inter-species crosstalk
Xenograft
Zebrafish
Online Access:http://dmm.biologists.org/content/9/2/141

Internet

http://dmm.biologists.org/content/9/2/141

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