Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been proposed as a strategy for an HIV cure whereby drugs and compounds referred to as latency-reversing agents (L...

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Bibliographic Details
Main Authors: Cory H. White, Nadejda Beliakova-Bethell, Steven M. Lada, Michael S. Breen, Tara P. Hurst, Celsa A. Spina, Douglas D. Richman, John Frater, Gkikas Magiorkinis, Christopher H. Woelk
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
human endogenous retroviruses
histone deacetylase inhibitor
primary CD4+ T cells
total RNA-Seq
long terminal repeat
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00603/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00603/full

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