Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH). Circulating levels of interleukin-1 (IL-1) are raised in patients and animal models. Whether interplay between BMP and IL-1 signaling can explain...

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Bibliographic Details
Main Authors: Josephine Pickworth, Alexander Rothman, James Iremonger, Helen Casbolt, Kay Hopkinson, Peter M. Hickey, Santhi Gladson, Sheila Shay, Nicholas W. Morrell, Sheila E. Francis, James D. West, Allan Lawrie
Format: Article
Language:English
Published: SAGE Publishing 2017-09-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045893217729096

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https://doi.org/10.1177/2045893217729096

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