Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Summary Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes. Here we demonstrate a novel role for this pathway in directly regulating mitochondrial bi...

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Bibliographic Details
Main Authors: Kira M. Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M. Land, Lee Stanyer, Masayuki Yamamoto, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Format: Article
Language:English
Published: The Company of Biologists 2013-06-01
Series:Biology Open
Subjects:
Nrf2
Keap1
Energy metabolism
Oxidative phosphorylation
Mitochondria
Online Access:http://bio.biologists.org/content/2/8/761

Internet

http://bio.biologists.org/content/2/8/761

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