Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)

Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)

Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. Extracellular ATP is known to signal through plasma membrane receptors of the P2Y and P2X families. Among the P2X receptors, P2X7 has attracted incre...

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Bibliographic Details
Main Authors: Mélanie Demeules, Allan Scarpitta, Catalina Abad, Henri Gondé, Romain Hardet, Carolina Pinto-Espinoza, Anna Marei Eichhoff, Waldemar Schäfer, Friedrich Haag, Friedrich Koch-Nolte, Sahil Adriouch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
P2X7
tumor
Adeno-associated virus
Nanobodies (VHH)
animal models
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01699/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01699/full

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