Serum markers of the extracellular matrix remodelling reflect antifibrotic therapy in bile-duct ligated rats.

Serum markers of the extracellular matrix remodelling reflect antifibrotic therapy in bile-duct ligated rats.

BackgroundProgression of liver fibrosis is characterized by synthesis and degradation of extracellular matrix (ECM). Matrix-metalloproteinases (MMP) cleave collagen fibers at a specific site and thereby generate soluble fragments of ECM (neo-epitopes). The levels of these neo-epitopes might reflect...

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Bibliographic Details
Main Authors: Robert eSchierwagen, Sabine eKlein, Diana Julie Leeming, Michaela eGranzow, Mette Juul Nielsen, Tilman eSauerbruch, Aleksander eKrag, Morten A Karlsdal, Jonel eTrebicka
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Physiology
Subjects:
Fibrosis
Statins
remodelling
ECM (extracellular matrix)
markers
antifibrotic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00195/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00195/full

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