ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]

Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that hydrolyze TGs and phospholipids in plasma lipoproteins. Here we describe the development and testing of a fully human monoclonal antibody (R...

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Bibliographic Details
Main Authors: Viktoria Gusarova, Corey A. Alexa, Yan Wang, Ashique Rafique, Jee Hae Kim, David Buckler, Ivory J. Mintah, Lisa M. Shihanian, Jonathan C. Cohen, Helen H. Hobbs, Yurong Xin, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Journal of Lipid Research
Subjects:
lipoprotein lipase
endothelial lipase
triglycerides
cholesterol
hyperlipidemia
dyslipidemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355504

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http://www.sciencedirect.com/science/article/pii/S0022227520355504

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