Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

by Yasu-Taka Azuma, Yukiko Matsuo, Hidemitsu Nakajima, George D. Yancopoulos, David M. Valenzuela, Andrew J. Murphy, Margaret Karow, Tadayoshi Takeuchi
Published 2011-01-01

Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature.

by Keiko Takahashi, Rachel Kim, Colette Lauhan, Yuna Park, Nghiep G Nguyen, Dietmar Vestweber, Melissa G Dominguez, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Nicholas W Gale, Takamune Takahashi
Published 2017-01-01

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S]

by Jorge F. Haller, Ivory J. Mintah, Lisa M. Shihanian, Panayiotis Stevis, David Buckler, Corey A. Alexa-Braun, Sandra Kleiner, Serena Banfi, Jonathan C. Cohen, Helen H. Hobbs, George D. Yancopoulos, Andrew J. Murphy, Viktoria Gusarova, Jesper Gromada
Published 2017-06-01

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]

by Viktoria Gusarova, Corey A. Alexa, Yan Wang, Ashique Rafique, Jee Hae Kim, David Buckler, Ivory J. Mintah, Lisa M. Shihanian, Jonathan C. Cohen, Helen H. Hobbs, Yurong Xin, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Published 2015-07-01

Activin A more prominently regulates muscle mass in primates than does GDF8

by Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Published 2017-04-01

Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.

by Ka-Man Venus Lai, Guochun Gong, Amanda Atanasio, José Rojas, Joseph Quispe, Julita Posca, Derek White, Mei Huang, Daria Fedorova, Craig Grant, Lawrence Miloscio, Gustavo Droguett, William T Poueymirou, Wojtek Auerbach, George D Yancopoulos, David Frendewey, John Rinn, David M Valenzuela
Published 2015-01-01

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

by Fabienne Billiard, Sevasti Karaliota, Bei Wang, Dimitrios Stellas, Ioannis Serafimidis, Antigoni Manousopoulou, Yiassemi Koutmani, Elpiniki Ninou, Jacquelynn Golubov, Amanda DaNave, Panagiotis Tsakanikas, Yurong Xin, Wen Zhang, Matthew Sleeman, George D. Yancopoulos, Andrew J. Murphy, Spiros D. Garbis, Katia Karalis, Dimitris Skokos
Published 2018-01-01

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

by Rene C. Adam, Ivory J. Mintah, Corey A. Alexa-Braun, Lisa M. Shihanian, Joseph S. Lee, Poulabi Banerjee, Sara C. Hamon, Hye In Kim, Jonathan C. Cohen, Helen H. Hobbs, Cristopher Van Hout, Jesper Gromada, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman, Viktoria Gusarova
Published 2020-09-01

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

by Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen
Published 2013-11-01

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

by Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen
Published 2013-12-01

Multiple knockout mouse models reveal lincRNAs are required for life and brain development

by Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn
Published 2013-12-01

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

by Viktoria Gusarova, Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, Michael F. Murray, Anubha Mahajan, Jonas B. Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F. Gudbjartsson, Marketa Sjögren, Connor A. Emdin, Robert A. Scott, Wen-Jane Lee, Aeron Small, Lydia C. Kwee, Om Prakash Dwivedi, Rashmi B. Prasad, Shannon Bruse, Alexander E. Lopez, John Penn, Anthony Marcketta, Joseph B. Leader, Christopher D. Still, H. Lester Kirchner, Uyenlinh L. Mirshahi, Amr H. Wardeh, Cassandra M. Hartle, Lukas Habegger, Samantha N. Fetterolf, Teresa Tusie-Luna, Andrew P. Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I. Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M. Brummett, Amit V. Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A. Lotta, Cristen J. Willer, Oddgeir L. Holmen, Marylyn D. Ritchie, David H. Ledbetter, Andrew J. Murphy, Ingrid B. Borecki, Jeffrey G. Reid, John D. Overton, Ola Hansson, Leif Groop, Svati H. Shah, William E. Kraus, Daniel J. Rader, Yii-Der I. Chen, Kristian Hveem, Nicholas J. Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Goncalo R. Abecasis, David Altshuler, Jose C. Florez, Michael Boehnke, Mark I. McCarthy, George D. Yancopoulos, David J. Carey, Alan R. Shuldiner, Aris Baras, Frederick E. Dewey, Jesper Gromada
Published 2018-06-01