Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice

Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice

Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH development are incompletely understood. We tested the hypothes...

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Bibliographic Details
Main Authors: Susanne Schuster, Casey D. Johnson, Marie Hennebelle, Theresa Holtmann, Ameer Y. Taha, Irina A. Kirpich, Akiko Eguchi, Christopher E. Ramsden, Bettina G. Papouchado, Craig J. McClain, Ariel E. Feldstein
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Lipid Research
Subjects:
oxylipins
nonalcoholic steatohepatitis
oxidative stress
thioredoxin-interacting protein
apoptosis signal-regulating kinase 1
NOD-like receptor protein 3
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033529X

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http://www.sciencedirect.com/science/article/pii/S002222752033529X

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