Nanog induces hyperplasia without initiating tumors

Nanog induces hyperplasia without initiating tumors

Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, many contradictory reports about Nanog's involvement in tumorigenesis exist. To address this, a modified Tet-On system was utilized to generate Nanog-inducible mice. F...

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Bibliographic Details
Main Authors: Gerrit Fischedick, Guangming Wu, Kenjiro Adachi, Marcos J. Araúzo-Bravo, Boris Greber, Martina Radstaak, Gabriele Köhler, Natalia Tapia, Roberto Iacone, Konstantinos Anastassiadis, Hans R. Schöler, Holm Zaehres
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506114000907

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http://www.sciencedirect.com/science/article/pii/S1873506114000907

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