TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression

TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression

Maintenance of regulatory T cells CD4+CD25highFOXP3+ (Treg) stability is vital for proper Treg function and controlling the immune equilibrium. Treg cells are heterogeneous and can reveal plasticity, exemplified by their potential to express IL-17A. TNFα-TNFR2 signaling controls IL-17A expression in...

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Bibliographic Details
Main Authors: Paulo C. M. Urbano, Xuehui He, Bennie van Heeswijk, Omar P. S. Filho, Henk Tijssen, Ruben L. Smeets, Irma Joosten, Hans J. P. M. Koenen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
Treg
FOXP3
TNF
anti-TNF
IL-17A
JAK
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03047/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03047/full

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