Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.
The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other canc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3735457?pdf=render |